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ABCG21 transport protein

A transporter protein is a protein in the blood that binds poorly soluble substances and transports them to another place in the body where they can be split off or released. The protein ABCG2 (ATP binding cassette G2) ensures the removal of substances to i.e., the intestines and kidneys. Via this mechanism the absorption of these substances into the blood is regulated. ABCG2 is not only involved in the transport of natural substances such as lipids, bile, uric acid and cholesterol, but also foreign substances such as medicines.

Uric acid is a toxic breakdown product that is removed from the body with the help of transport protein ABCG2. Allopurinol is used to reduce the uric acid concentration.
The activity of the ABCG2 transport protein can vary considerably depending on your genetic predisposition, which may lead to differences in the effectiveness and potential side effects of allopurinol from person to person. Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with allopurinol.

Note: Mutations in the HLA-B*5801 gene can increase the risk of severe adverse reactions to allopurinol, but these are not mapped. The HLA-B*5801 allele is present in 1-2% of Europeans and Japanese individuals, while its prevalence among Han Chinese can be as high as 20%.

Read more about Allopurinol (ABCG2) »

Uric acid is a toxic breakdown product that is removed from the body with the help of transport protein ABCG2. Allopurinol is used to reduce the uric acid concentration. The activity of the ABCG2 transport protein can vary considerably depending on your genetic predisposition, which means the extent and nature of potential side effects of allopurinol can differ from person to person. Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with allopurinol.

Note: Mutations in the HLA-B*5801 gene can increase the risk of severe adverse reactions to allopurinol, but these are not mapped. The HLA-B*5801 allele is present in 1-2% of Europeans and Japanese individuals, while its prevalence among Han Chinese can be as high as 20%.

Read more about Allopurinol (ABCG2) »

Genetic predisposition The activity of the ABCG2 transporter varies between individuals. This variation can be partly explained by genetic differences in the ABCG2 gene. A decreased ABCG2 activity is very common in people of East Asian origin (29-50%), common in people of European (9-17%), Latin American (14-22%) and South Asian origin (9%) and rare in people of African origin (2%). When establishing a genotype, these differences in the ABCG2 gene are indicated by the nucleotide number followed by the nucleotide change. An example of a possible ABCG2 genotype is 141KQ.
The following variant of the ABCG2 gene is determined: Q141K (rs2231142).

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